Its establishment was made possible by the collaboration of the Taguig City Government under Mayor Sigfrido R. Tiñga with the SDO-TaPat, then under Schools Division Superintendent, Jovita O. Calixihan.

In June 2002, a special science class with 35 students each section was established at Signal Village National High School for the academic year of 2002-2003.

On March 12, 2004, The request of the local government for allocation of funds in the amount of Thirty Million Pesos (P30.0 M) for the construction of a two-storey (12 classrooms) school building with laboratories for the proposed Taguig Science and Technology Multi-Purpose Hall was referred to the DepEd-NCR by the Planning Office of DepEd, Central Office.

On March 29, 2004, The Regional Office denied the request of the local government re: the appropriation for the construction of the proposed Taguig Science High School.

104, s. 2003 and requested the Division Office to submit the requirements for the establishment of Taguig Science High School as stipulated in DepEd Order No.

The reports brought the #TagSciDoBetterNow hashtag viral, with Senator Risa Hontiveros and Kabataan partylist representative Sarah Elago defending the students and calling for government investigation into the manner.

On October 29, the school administration announced the formation of an investigative committee for the reported cases and other measures to protect students from harassment.