[7] Situated on an 800-dunam (0.80 km2; 0.31 sq mi) campus in east Ramat Gan, Sheba operates 120 departments and clinics.

Eight Kurdish infants in need of emergency cardiac surgery were operated on in Israel by Sheba's pediatric cardiac-thoracic surgeons.

[18] In 2021, the United Arab Emirates (UAE) announced the signing of a Memorandum of Understanding (MoU) with Sheba Medical Center.

According to a statement released by the Emirates News Agency, the MoU aims to "create a framework for cooperation in developing and improving healthcare services to meet the needs of a healthier community.

[citation needed] In 2011, Sheba topped the list of Israeli hospitals for revenue acquired through research, at NIS 42.4 million, but came in second in 2012.

[23] The Israeli company Ventor Technologies developed a novel type of heart valve which can be implanted by catheterization rather than open-heart surgery at Sheba.

[24] In October 2020, the hospital piloted a rapid coronavirus test that detects protein portions of the virus and yields results within two to 15 minutes.

[25] Established in 2002 with the support of the Edmond J. Safra Foundation, the pediatric section of the Medical Center features diagnosis as well as treatment in numerous specialized clinics for children: Premature, intensive care, haemato-oncology and stem cell transplantation, surgery, Louis-Bar syndrome, radiology and imaging, oncology, gastroenterology, immunology, rheumatology, and surgery of congenital malformations.

The hospital provides treatments for children from Israel as well as from the neighbouring Palestinian Authority[26] and from other regions in the Middle East.

It has notably treated some of the hostages released after the Hamas terrorist attack on October 7, 2023[28] and was praised for its readiness to provide immediate physical and psychological care.

Two days later, he was found dead by the side of Route 443, barefoot, still wearing a hospital gown, a catheter and a diaper.

In 2012, two Israeli police officers involved were convicted of negligent homicide and were sentenced to two and a half years in prison.

[33] In 2014, during 2014 Israel–Gaza conflict, a Palestinian nurse of the clinic posted on Facebook that “the Israel Defense Forces are war criminals, only killing innocent people, and the state is claiming [it is done] 'by mistake and we are investigating the incident.