The highway begins at a junction with Spur 241 in Hidalgo and heads north to a junction with State Highway 107 (SH 107) in Edinburg.

SH 336 was designated on November 22, 1940 to serve as a route between Hidalgo and Edinburg.

[1] SH 336 begins at a junction with Spur 241 in Hidalgo.

It heads north from this junction to an intersection with FM 1016 in McAllen.

The highway continues north through McAllen to an intersection with SH 495.