Its melting point lies above 1000 °C, and has extremely low solubility in water.

While it contains antimony and nickel, their bioavailability is very low, so the pigment is relatively safe.

[citation needed] The pigment has crystal lattice of rutile, with 2–5% of titanium ions replaced with nickel(II) and 9–12% of them replaced with antimony(III).

Titanium yellow is manufactured by reacting fine powders of metal oxides, hydroxides, or carbonates in solid state in temperatures between 1000 and 1200 °C, either in batches or continuously in a pass-through furnace.

Titanium yellow is used primarily as a pigment for plastics and ceramic glazes, and in art painting.