[12][13][14][15] Triadin is required to physically link the RYR2 and CASQ2 proteins, so that RYR2 channel activity can be regulated by CASQ2.

[8][9][10][17] Luminal concentration levels of Ca2+ are sensed by CSQ, and this information is transmitted to RyR via Triadin.

At low luminal Ca2+ concentrations, Triadin is bound to both RYR2 and CASQ2, so that CSQ prevents RYR2 from opening.

At high luminal Ca2+ concentrations, Ca2+ binding sites on CASQ2 become occupied with Ca2+, leading to a weakened interaction between CASQ2 and Triadin.

[18] A deletion of amino acids in the TRDN gene can result in an early stop codon.