Trisobbio is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 80 kilometres (50 mi) southeast of Turin and about 30 kilometres (19 mi) south of Alessandria.

Trisobbio borders the following municipalities: Carpeneto, Cremolino, Montaldo Bormida, Morsasco, Orsara Bormida, Ovada, and Rocca Grimalda.

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