Viguzzolo is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 100 kilometres (62 mi) east of Turin and about 25 kilometres (16 mi) east of Alessandria.

As of 31 December 2004, it had a population of 2,964 and an area of 18.3 square kilometres (7.1 sq mi).

[3] Viguzzolo borders the following municipalities: Berzano di Tortona, Casalnoceto, Castellar Guidobono, Pontecurone, Sarezzano, Tortona, and Volpeglino.

Already mentioned in ninth-century documents, it was a free commune and in 1278 obtained Tortona citizenship.

With the arrival of the Sforza family, it was forced into public submission, under threat of destruction.