Villalvernia is a comune, population 932, in the Province of Alessandria in Piedmont, Italy, situated in a hilly area on the right bank of the Scrivia.

Probably founded during the 10th century, and simply called Villa, the town was partially enfeoffed to the bishops of Tortona by Pope Adrian IV (Nicholas Breakspear).

In 1580, after the wedding of Francesco with Antonia Alvernia, the feud passed to the Spinola family.

In 1652 the feudatories obtained the title of Marquess from Philip IV, King of Spain.

On 1 December 1944, the village was bombed by the United States Air Force; 105 inhabitants were killed and 253 were injured.