Volpedo borders the following municipalities: Casalnoceto, Godiasco, Monleale, Montemarzino, Pozzol Groppo, and Volpeglino.

In the 12th century it was known as Vicus pecudis, and was connected to the comune of Tortona, sending relief troops to that city during the siege laid by Frederick Barbarossa in 1155.

[5] In 1347 Tortona was annexed by the Visconti of Milan who, in 1412, gave Volpedo as a fief to the condottiero Pierino Cameri.

[6] In 1738 Volpedo, together with all the area of Tortona, was acquired by the Kingdom of Sardinia (Piedmont), and was given as a fief to marquis Filippo Guidobono Cavalchini.

[7] In the 19th century part of the walls were progressively dismantled, and in 1856 the Curone bridge, linking Volpedo with Monleale, was built.