[8] Originally launched under the name Obtainium in 2014,[9] and later known as Opus 12,[10] Twelve was officially founded in 2015 by Dr. Kendra Kuhl, Dr. Etosha Cave, and Nicholas Flanders.

[19] Twelve has also been featured on the television show Inside Bill's Brain as a company providing a potential solution to greenhouse gas emissions.

[23][24] Twelve utilizes polymer electrolyte membrane electrolysis, which splits apart water molecules into its component pieces (O2, electrons, and hydrogen ions) via the application of electricity.

[26] In June 2020, the company partnered with SoCalGas and PG&E to advance their technology for use with CO2 present in biogas, which comes from sources such as landfills, sewage, and dairy farms.

[27] This gas, produced by the anaerobic breakdown of wastes, contains roughly 60% methane and 40% CO2; testing is being performed with the goal of achieving high conversion efficiency for long periods of time.