One lane of westbound US 50 Business continues beyond the ramp to an intersection with Stanton Avenue, a service road for residences detached from US 50 when the interchange was built.

[1][2] After crossing the North Prong of the Wicomico River on a drawbridge, the business route intersects Division Street, the original alignment of US 13.

The business route returns to four lanes after the intersection with MD 346 (Main Street), which is the original alignment of US 50.

A park and ride lot is located at the southeast corner of the Phillip Morris Drive intersection.

Shortly after the intersection with Tilghman Road, the business route reaches its eastern terminus at a partial cloverleaf interchange with the Salisbury Bypass, which features US 13 and US 50 west.

[1][3] The original east–west highway through Salisbury entered the city from Hebron along its present course from the northwest to Isabella Street.

First, the SRC took over maintenance of the drawbridge over the North Prong of the Wicomico River in 1924 and completed its replacement in 1928.

US 50 west of Isabella Street was expanded to a four-lane divided highway northwest to Naylor Mill Road in 1954.