begins at a partial interchange with US 13, which continues south as Ocean Highway and heads north as the Salisbury Bypass.

Upon entering the city of Fruitland, the business route intersects Camden Avenue, which is an old alignment of US 13.

The highway continues north and intersects MD 513 (Cedar Lane) in a commercial area before leaving Fruitland by traversing Tonytank Pond.

At the northern edge of the campus, the business route meets College Avenue and reduces to a five-lane undivided highway with center turn lane.

performs an S-curve to the east and crosses Division Street right after the highway again begins to closely parallel the Delmarva Subdivision railroad track.

The business route crosses the South Prong of the Wicomico River and intersects Main Street, the old alignment of US 50.

intersects Isabella Street and passes historic Union Station before crossing the Delmarva Central Railroad's Mardela Industrial Track line.

US 13 Business crosses Peggy Branch and passes through a commercial area, heading northwest of the WBOC-TV studios, before expanding to a divided highway again immediately before its northern terminus at the Salisbury Bypass adjacent to The Centre at Salisbury shopping mall.

[1][3] The original north–south highway through Fruitland and Salisbury followed Allen Road north from Allen on Wicomico County's border with Somerset County to near the present intersection of Division Street and Camden Avenue on the west side of Fruitland.

[5] The state road was completed from the southern limit of Salisbury to Main Street in Fruitland in 1912 and from there to Allen in 1913.

[8] The first upgrade to US 13 in the Salisbury–Fruitland area occurred in 1930 when Division Street north of downtown Salisbury was placed on an overpass over the New York, Philadelphia and Norfolk Railroad.

[9] In addition, an eight-mile (13 km) section of straight highway mostly paralleling the railroad tracks between Princess Anne and Camden Avenue west of Fruitland opened in 1933.

[12] The third and final section, from Main Street to Zion Road on the north side of Salisbury, was completed by 1942.