Research activities are realized in the laboratories, computer classrooms, and Center for Advanced Study in Natural and Mathematical Sciences.

The Faculty educates future teachers of mathematics, computer science, physics, chemistry, biology, and geography for work in primary and secondary schools; research scientists for work at universities, research institutes and other scientific institutions; professionals for work in the government institutions, public sector enterprises, insurance agencies, banks and other financial organizations, ICT companies, travel agencies, tourism organizations, etc.

The academic stuff at the Faculty takes part in scientific conferences and professional symposia in the country and abroad.

The Faculty publishes the academic journal Filomat (IF 0.753) which features articles in the fields of mathematics and computer science.

The academic staff at the Faculty also takes part in the publishing of the two series of the journal Facta Universitatis – Physics, Chemistry and Technology and Mathematics and Informatics.

For the purpose of fostering the educational process, 146 textbooks, workbooks, and monographs authored by the Faculty's academic staff have been published.