[8] It has five schools (Medicine, Nursing, Health Professions, Public and Population Health, and Graduate Biomedical Sciences), three institutes for advanced study, a comprehensive medical library, four on-site hospitals (including an affiliated Shriners Hospital for Children), a network of clinics that provide primary and specialized medical care and numerous research facilities.

The medical school campus also included the John Sealy Hospital, which provided charity care for any who claimed Galveston residence.

Upon opening, the Red Building had been starkly underfurnished, a problem which was not fully remedied until after the Hurricane of 1900, when the state rallied around the ravaged city.

Dr. Thompson, professor of surgery, said that "the regents were so generous in repairing the damage to the building and restoring the equipment, that we were actually in better shape at the end of the year 1901 than we had been before."

[12] UTMB's annual budget of approximately $1.4 billion includes grants, awards, and contracts from federal and private sources totaling more than $150 million, in addition to institutional allocations for research.

[citation needed] Construction on an emergency department began in 1989, and the Sealy & Smith Foundation spent $28 million to have it built.

[15][16] In 2011 the foundation committed $170 million towards the construction of a new Jennie Sealy Hospital on the UTMB campus, an amount that represents the largest single gift ever to a Texas health institution.

[17] In 2003, UTMB received funding to construct a $150 million Galveston National Biocontainment Laboratory on its campus, one of the few non-military facilities of this level.