Uterine clear-cell carcinoma (CC) is a rare form of endometrial cancer with distinct morphological features on pathology; it is aggressive and has high recurrence rate.
Like uterine papillary serous carcinoma CC does not develop from endometrial hyperplasia and is not hormone sensitive, rather it arises from an atrophic endometrium.
[1] The lesion is found in patients who present typically with abnormal or postmenopausal bleeding or discharge.
FIGO-cancer staging is done at the time of surgery which consists of peritoneal cytology, total hysterectomy, bilateral salpingo-oophorectomy, pelvic/para-aortic lymphadenectomy, and omentectomy.
[4] IA Tumor confined to the uterus, no or < 1⁄2 myometrial invasion IB Tumor confined to the uterus, > 1⁄2 myometrial invasion II Cervical stromal invasion, but not beyond uterus IIIA Tumor invades serosa or adnexa IIIB Vaginal and/or parametrial involvement IIIC1 Pelvic node involvement IIIC2 Para-aortic involvement IVA Tumor invasion bladder and/or bowel mucosa IVB Distant metastases including abdominal metastases and/or inguinal lymph nodes