[citation needed] The lesion is found in patients who present typically with abnormal or postmenopausal bleeding.

[3] In 2009, the journal of "Gynecologic Oncology" reported the following 5-year survival rates based upon stage of cancer: The primary treatment is surgical.

FIGO-cancer staging is done at the time of surgery which consists of peritoneal cytology, total hysterectomy, bilateral salpingo-oophorectomy, pelvic/para-aortic lymphadenectomy, and omentectomy.

[4] In a study to determine if adjuvant therapy should be used in patients with stage I uterine papillary serous carcinoma who had undergone surgery, no increased survival was seen when radiation therapy was added versus observation, while the postsurgical treatment with chemotherapy may be beneficial but more data are needed.

[8] Prognosis of uterine papillary serous carcinoma is affected by age, stage, and histology as well as treatment.