A typical example of this occurs when fibrinogen displaces earlier adsorbed proteins on a biopolymer surface and is later replaced by high molecular weight kininogen.
Under stagnant conditions initial protein deposition takes place in the sequence: albumin; globulin; fibrinogen; fibronectin; factor XII, and HMWK.
[3] While the exact mechanism of action is still unknown many important protein physical properties play a part in the Vroman Effect.
This simple model lacks in complexity, since Vroman-like behavior has been observed on hydrophobic surfaces as well as hydrophilic ones.
[4][5] Furthermore, adsorption and desorption doesn't completely explain competitive protein exchange on hydrophilic surfaces.
This model explains the kinetics between reversible adsorption and desorption, assuming the adsorbate behaves as an ideal gas at isothermal conditions.