It is located in the center of Orlando's historic Parramore district, at 511 West South Street.

Dr. William Monroe Wells built the hotel, and a nearby entertainment venue, for African Americans visiting Orlando.

Dr. William M. Wells was a prominent African-American physician in Orlando during the first half of the 20th century.

Although the Casino is gone, the original hotel remains and has been converted into a modest museum of African American history.

Exhibits include a 1930s period hotel guestroom with authentic furniture, beading and decorations,[2] the South Street Casino, the Chitlin' Circuit performance hall that was formerly located next to the hotel, artifacts from Dr. William Monroe Wells, and other elements of Orlando's African American heritage.