After several tenths of a mile, the stream turns west and then north-northwest, crossing US Route 522 and approaching Thomas Ridge.

Here, the stream disappears from the surface and turns west for several tenths of a mile before reaching its confluence with Kern Run.

[1] Beaverton Finishing Farm has or had a National Pollutant Discharge Elimination System permit for which the receiving stream was Wetzel Run.

[2] Flooding has been known to occur on Wetzel Run near the borough of Beavertown and in Beaver Township.

[6] Wild trout naturally reproduce in Wetzel Run for 3.59 miles (5.78 km) of its length.