Winfield Creek (also known as Dry Run) is a tributary of the West Branch Susquehanna River in Union County, Pennsylvania, in the United States.

It flows southwest for a short distance before turning south and entering a much broader valley.

It flows in this direction through the valley for several miles, running alongside Pennsylvania Route 304 and entering the census-designated place of Winfield.

A short distance further downstream, it reaches its confluence with the West Branch Susquehanna River.

[6] The creek flows through a narrow valley, which is bordered by Shamokin Mountain on the north and highlands on the south.

[9] A concrete tee beam bridge carrying US Route 15 over Winfield Creek was constructed in 1930 and repaired in 1962.

A two-span concrete culvert bridge carrying State Route 2009 over the creek was built in 1991.

[6] A. Joseph Armstrong described the creek as "not worth further investigation" in his book Trout Unlimited's Guide to Pennsylvania Limestone Streams.