They had hoped to keep white Americans out of their territory and to make the Ohio River the border between the United States and Canada.

They were transported to the current Wyandotte County in 1843, where they set up a community and worked in cooperation with Anglo settlers.

[5] The Wyandot in Kansas set up a constitutional form of government they had devised in Ohio.

[6] Tenskwatawa (Tecumseh's brother), "the Prophet", fought at the Battle of Tippecanoe in 1811.

The ore and base bullion is received from the mountains' mining districts and is crushed, separated and refined.

In January 2025, Wyandotte County was the epicenter of the largest tuberculosis outbreak in United States history according to the Kansas Department of Health and Environment (KDHE).

[11][12] The creek has disastrously flooded the area through all measurable history, including several cities in the Upper Turkey Creek Basin, for which the U.S. Army Corps of Engineers has developed complicated flood control deployments and ongoing proposals, including major drainage at Rosedale, KCK.

Wyandotte County was a prohibition, or "dry", county until the Kansas Constitution was amended in 1986 and voters approved the sale of liquor by the individual drink with a 30% food sales requirement.

[21] The county voted against the 2022 Kansas abortion referendum, an anti-abortion ballot measure, by 74% to 26%, outpacing its support of Joe Biden during the 2020 presidential election.

Voters at the time largely decided the municipal government harbored widespread corruption and patronage, and that consolidation with the better run county offered a path toward better public services and increased government transparency.

This is largely due to its highly urbanized nature and significant minority population.

Wyandotte was the only county in Kansas to vote for Franklin D. Roosevelt in 1944, Adlai Stevenson II in both 1952 and 1956, Hubert Humphrey in 1968, Jimmy Carter in 1980, and Walter Mondale in 1984.

Democratic strength is primarily concentrated east of Interstate 435, while areas west of the highway, especially the neighborhoods of Piper and Wolcott, lean Republican.

[25] Village West is at the intersection of Interstates 70 and 435, and has significantly fueled growth in KCK and Wyandotte County.

Anchored by the Kansas Speedway, its attractions and retailers include Hollywood Casino, Legends Outlets Kansas City, Cabela's, Nebraska Furniture Mart, Great Wolf Lodge, Legends Field (hosting the Monarchs of the American Association of baseball) and Children's Mercy Park (hosting Sporting Kansas City of Major League Soccer).

Other attractions include Azura Amphitheater (formerly and still commonly known as the Sandstone Amphitheater), the National Agricultural Center and Hall of Fame, Wyandotte County Park, and Sunflower Hills Golf Course.