1D4U, 1XPA, 2JNW750722590ENSG00000136936ENSMUSG00000028329P23025Q64267NM_000380NM_011728NP_000371NP_001341904NP_035858DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.

[4] Nucleotide excision repair (NER) is a major pathway for repairing a variety of bulky DNA damages including those introduced by UV irradiation.

The XPA protein appears to play a key role in NER at sites of damage as a scaffold for other repair proteins in order to ensure that the damages are appropriately excised.

[6] Xpa mutant individuals often show the severe clinical symptoms of xeroderma pigmentosum, a condition involving extreme sensitivity to sunlight and a high incidence of skin cancer.

XPA has been shown to interact with ERCC1,[6][7] Replication protein A1[8] and XAB2.