The UKTI office for the region was off the A653, directly south of Bridgewater Place in Holbeck, and its successor (in July 2016) DIT Yorkshire and the Humber is at the Digital Media Centre near Barnsley Interchange, run by Mark Robson.

NHS Yorkshire and the Humber, the regional strategic health authority, was at the roundabout at the bottom of Kirkstall Road in Leeds, with another office in the north of Sheffield.

TSC Foods on the Queensway Industrial Estate at the A18/A1029 roundabout in south-east Scunthorpe supply many foodservice products (sauces) to most UK pub chains.

Cofely Fabricom Engie (former GDF SUEZ), an engineering consultancy based on the A1173 in Immingham, work in the oil and gas industry, and nearby to the east is a large Knauf plaster board plant.

In Healing (former Little Coates) next to the Humber, Lenzing Fibers Grimsby make Lyocell (Tencel), where it was first made by Courtaulds in 1988, who owned the site until bought by AkzoNobel in 1998.

Smith & Nephew (wound management division) and Reckitt Benckiser medical and household products companies originated in Hull, and still have large factories there.

Heron Frozen Foods is based there near St Andrew's Quay, and Cranswick plc are a food-processing company based in the north of Hull, which makes up-market (Taste the Difference) gourmet sausages for Tesco and Sainsbury's, and The Black Farmer, in West Carr; Cranswick Country Foods have their main poultry processing site off the B1237 in the north of Stoneferry.

Fenner Dunlop Europe who claim to be the world's largest conveyor belt manufacturer, in Marfleet, have their own cricket pitch and their Hainsworth Research Centre.

RAF Fylingdales is an important, though secret, part of NATO's Ballistic Missile Early Warning System; the Emergency Planning College at Easingwold provided courses to prepare for nuclear war.

The Shepherd Building Group (who own Portakabin), and Portasilo, which makes bulk handling equipment such as silos, are in Huntington off the A1036 in the east of York; AlphaGraphics UK are next door (formerly in Seamer), and to Monks Cross retail park.

Rolawn at the Laveracks Industrial Estate on the B1228 in Elvington is Europe's largest producer of lawn turf, with its Medallion brand being the UK market leader.

Tangerine Confectionery is off the A59, in Acomb Ings in the west of York, which makes toffee and fudge; its old site on Coppergate is now Jorvik Viking Centre; the neighbouring British Sugar plant closed in 2007.

HSBC opened their first UK call centre in the city, taking advantage of its advanced communications network which also led to the founding of Freeserve in Leeds.

Ellie Louise, a clothes retailer, is at Sturton Grange north of Garforth on the A642, south of M1 junction 47 on the Helios 47 Industrial Estate, near Ginetta Cars.

Agfa Graphics (Belgian) have their only UK factory next to Fabergé in Whinmoor, making computer to plate offset printers; 85% of the world's banknotes are printed with the parent company's technology.

[citation needed] Morrisons is based in Bradford; it has 132,000 staff and opened its first supermarket in 1961 in a converted cinema; it turned over £17.6 billion in 2015, and is the region's second largest company.

Crosslee plc, south of Hipperholme on the A644 towards Brighouse, is Europe's largest independent tumble dryer manufacturer, under the White Knight brand.

Many fabric companies are in Huddersfield and the surrounding areas; Taylor & Lodge, owned by Bulmer & Lumb of Bradford, wove cloth for the 2011 Royal Wedding; Dugdale Bros & Co are in the centre.

LPA Group off the A655 in Hopetown, Normanton makes LED lighting for trains; Poundworld was founded on a Wakefield market in 1974, and the family-owned company has 240 shops.

Nooter/Eriksen UK is off the A636 next to Denby Dale railway station, and produce heat recovery steam generator (HRSGs) Sheffield is known for its steel industry, which has declined in recent years.

Polestar is on the A631 in former Brinsworth, now in Sheffield (Tinsley).On the opposite side of the A631 is Betafence UK, part of the world's main fencing manufacturer, and its second biggest plant; near the start of the A631 is Tuffnells Parcel Express (owned by Connect Group since 2014).

SIG plc (Europe's largest insulation distributor) and Stanley Tools UK are at the former city airport, with a manufacturing plant off the A631 on the Hellaby Industrial Estate next to the M18, and had a former site on the B6075 in Sheffield.

Siemens VAI UK is on Sheffield Business Park near the former airport, with EVO Group, who own the Banner stationery company, and Ansys (Fluent and CFX computational fluid dynamics software) has one of two main offices.

Go Outdoors, owned by JD Sports since 2016, are in the south of Sheffield, near Bramall Lane off the A61; Hi Gear Products, their brand is on the Boston Street Industrial Estate.

The Primary Mill makes steel billets and blooms – continuous casting with an electric arc furnace with a melting shop, and is also known as Aldwarke Works.

Laycast were nearby until November 2006, based off the B6200 at Aston cum Aughton, at which steel flywheels, vibration dampers and compacted graphite iron clutch plates were cast at its foundry.

MGB Plastics, on the A6123 in north Rotherham on Barbot Hall Industrial Estate, are the UK's largest manufacturer of wheelie bins, making around 1 million per year.

Unipart have a headquarters next to Wabtec, who make railway air brakes, off the A6182 near Potteric Carr at the J3 Business Park, near VolkerRail; nearby are two Amazon fulfilment centres, with another at the Doncaster iPort in Rossington.

Pegler Yorkshire (owned by Aalberts) are near the A630 in Balby Carr, further along from Bridon, with MSI-Quality Forgings opposite with Global-MSI who manufacture petrol station forecourts.

Polestar Petty in central Leeds, with web offset, for many years printed TVTimes, Radio Times, and many colour supplements, including the Daily Mail weekend magazine, but closed in December 2014.