The 18th Mississippi Infantry Regiment was a unit of the Confederate States Army that took part in many battles of the Eastern Theater of the American Civil War.

The troops immediately proceeded via rail to Virginia, where the 18th took part in the First Battle of Bull Run in July.

[7] In 1863, the regiment fought at the Second Battle of Fredericksburg during the Chancellorsville Campaign, with the 18th posted at the stone wall on Marye's Height where Confederate defenders took major casualties.

By January 1864 the 18th Mississippi had been reduced to a strength of 220 men,[9] and by the summer the regiment had been so decimated by losses that it had no serving field officers, as noted in a letter from Confederate President Jefferson Davis to General Robert E.

Following Early's defeat, the 18th was moved to defend Richmond, and the remnants of the regiment surrendered at Appomattox Court House on April 9, 1865.