The 2004–05 Southern Illinois Salukis men's basketball team represented Southern Illinois University Carbondale during the 2004–05 NCAA Division I men's basketball season.
The Salukis were led by first-year head coach Chris Lowery and played their home games at the SIU Arena in Carbondale, Illinois as members of the Missouri Valley Conference.
The Salukis were eliminated in the semifinal round of the MVC tournament, but received an at-large bid to the NCAA tournament as No.
10 seed Saint Mary's[2] before falling to No.
2 seed Oklahoma State in the round of 32.