QB Jon Kitna completed a 13-yard TD pass to WR Roy Williams and kicker Jason Hanson connected on a 46-yard field goal.

In a wild fourth quarter, Hanson gave Detroit a 46-yard field goal, yet the Raiders took the lead with McCown's 7-yard TD pass to FB Justin Griffith.

at Ford Field, Detroit, Michigan Following their road win over the Raiders, the Lions played their Week 2 home opener against their NFC North rival Minnesota Vikings for the lead in the division.

In the third quarter, when Kitna was temporarily out with a concussion, QB J. T. O'Sullivan came in and completed a 7-yard TD pass to Calvin Johnson to increase Detroit's lead.

Minnesota, however, tied the game up with kicker Ryan Longwell getting a 32-yard field goal and DE Ray Edwards returning a fumble 9 yards for a touchdown.

However, in the second quarter, the Bears took the lead with QB Brian Griese (Rex Grossman was benched prior to the game) completing a 15-yard TD pass to WR Muhsin Muhammad for the only score of the period.

Afterwards, a high-flying fourth quarter began with QB Jon Kitna completing a 4-yard TD pass to WR Shaun McDonald, along with DB Keith Smith returning an interception 64 yards for a touchdown, giving the Lions the lead.

In the fourth quarter, the Redskins sealed Detroit's fate with Campbell completing an 8-yard TD pass to Sellers, kicker Shaun Suisham nailing a 28-yard field goal, and CB Carlos Rogers returning an interception 61 yards for a touchdown.

In the first quarter, Detroit attacked first with kicker Jason Hanson getting a 34-yard field goal, along with RB Kevin Jones getting a 1-yard TD run.

In the third quarter, the Bears threatened Detroit's lead as QB Brian Griese completed a 20-yard TD pass to TE Greg Olsen for the only score of the period.

at Ford Field, Detroit, Michigan Coming off their season-sweeping road win over the Bears, the Lions went home for a Week 9 interconference duel with the Denver Broncos.

In the second quarter, the Lions increased their lead with Hanson kicking a 53-yard field goal and QB Jon Kitna completing a 15-yard TD pass to WR Mike Furrey.

In the third quarter, the Lions continued their domination as DE Dewayne White returned a fumble 3 yards for a touchdown and Kitna completed a 49-yard TD pass to WR Shaun McDonald.

In the fourth quarter, Detroit sealed Denver's doom with NT Shaun Rogers returning an interception 66 yards for a touchdown and RB T. J. Duckett scoring on a 3-yard TD run.

This mark has since been passed by the Cleveland Browns, who went 4–48 from 2014 to 2017. at Ford Field, Detroit, Michigan Hoping to rebound from their tough road loss to the Cardinals, the Lions went home for a Week 11 intraconference duel with the New York Giants.

In the first quarter, Detroit trailed early as Giants kicker Lawrence Tynes managed to get a 28-yard field goal for the only score of the period.

In the second quarter, the Lions continued to trail as QB Eli Manning completed a 10-yard TD pass to RB Brandon Jacobs as the only score.

The Lions tried to mount a comeback as QB Jon Kitna completed a 35-yard TD pass to WR Calvin Johnson, but New York managed to hold on for the win.

at Ford Field, Detroit, Michigan Trying to snap a two-game skid, the Lions stayed at home for a Week 12 Thanksgiving divisional duel with the Green Bay Packers.

Detroit continued to try to come back as Hanson kicked a 52-yard FG, yet Green Bay was one step ahead as Favre completed a 3-yard TD pass to WR Ruvell Martin.

at Ford Field, Detroit, Michigan Trying to end a four-game skid, the Lions went home for a Week 14 intraconference duel with the Dallas Cowboys.

In the second quarter, the Lions' struggles continued as Kaeding kicked a 22-yard field goal and LB Shaun Phillips returning an interception 18 yards for a touchdown.

In the third quarter, the Chargers continued their domination as RB Darren Sproles managed to get a 1-yard TD run, while Kaeding nailed a 45-yard field goal.

With their sixth-straight loss, the Lions fell to 6–8 and were eliminated from playoff contention the next day when the Minnesota Vikings defeated the Chicago Bears 20–13.

In the second quarter, the Lions opened up a 19–0 lead with a Jason Hanson field goal and a Paris Lenon interception return for a touchdown.

Kansas City fought back with a Jackie Battle 3-yard run and a 1-yard pass from Damon Huard to Jared Allen to make it 19–14, but the Lions’ Jason Hanson added two more field goals in the second half and the Chiefs could not convert a two-point conversion to Tony Gonzalez in the 3rd after a Dwayne Bowe receiving TD.

This remained the Lions last regular-season victory until the third week of the 2009 season, when they would beat the Washington Redskins 19–14 after nineteen consecutive losses including all sixteen games in 2008. at Lambeau Field, Green Bay, Wisconsin Looking for their first win in the state of Wisconsin since 1991, the Lions headed to Lambeau Field for their second game of the year against Brett Favre and the Green Bay Packers.

The teams exchanged field goals to start the third quarter, but on 4th and 2, Craig Nall found Ruvell Martin for a 32-yard score, putting the Packers up 31–13, icing the game.