After four games, the team failed to equal their 14–2 2006 regular season record, as they immediately stumbled to a bad 1–3 start under new head coach Norv Turner.
After a postseason loss to the New England Patriots, offensive and defensive coordinators Cam Cameron and Wade Phillips left for new coaching jobs with the Miami Dolphins and Dallas Cowboys respectively.
In this defensive slugfest, the Bears held RB LaDainian Tomlinson, the previous year's league MVP, to just 25 yards rushing on 17 attempts, while getting a 27-yard field goal from kicker Robbie Gould in the second quarter.
In the third quarter, San Diego started to bounce back as Tomlinson threw his 7th career touchdown pass to TE Antonio Gates from 17 yards out.
Following their low-scoring home win over the Bears, the Chargers flew to Gillette Stadium for a Week 2 Sunday night fight against the New England Patriots in a rematch of last year's AFC Divisional game.
In the first quarter, San Diego trailed early as the Patriots took their opening drive and ended it with QB Tom Brady completing a 7-yard TD pass to TE Benjamin Watson.
In the second quarter, the Chargers continued to show last week's first half struggles as Patriots kicker Stephen Gostkowski getting a 24-yard field goal, while LB Adalius Thomas intercepted one of QB Philip Rivers' passes and returned it 65 yards for a touchdown.
Trying to rebound from their primetime road loss to the Patriots, the Chargers flew to Lambeau Field for Week 3, as they played an interconference game with the Green Bay Packers.
In the second quarter, Green Bay took the lead with QB Brett Favre completing a pair of 5-yard TD passes, one to WR Donald Driver and one to TE Bubba Franks.
In the first quarter, San Diego's struggling offense found some life with kicker Nate Kaeding getting a 24-yard field goal, while RB LaDainian Tomlinson got a 5-yard TD run.
In the third quarter, the Chargers lost their lead, with Kansas City getting a 41-yard field goal from Rayner and QB Damon Huard completing a 22-yard TD pass to TE Tony Gonzalez.
Even worse, San Diego ended up losing in the fourth quarter with Huard completing a 51-yard TD pass to WR Dwayne Bowe, along with CB Tyron Brackenridge returning a fumble 50 yards for a touchdown.
After speculation about the games location because of the ongoing California wildfires, it was confirmed on October 26, 2007, that Qualcomm Stadium would no longer be an evacuation site for San Diego residents, with most of the evacuees moved to Del Mar.
After an emotional home win over the Texans, the Chargers flew to the Hubert H. Humphrey Metrodome for a Week 9 interconference duel with the Minnesota Vikings.
After a Nate Kaeding field goal, Sproles returned a punt 45 yards for his second special teams touchdown of the game with less than 6 minutes left in the first quarter.
Manning set a franchise record by throwing six interceptions in one game (3 to Antonio Cromartie and one apiece to Clinton Hart, Matt Wilhelm, and Shaun Philips).
In the first quarter, San Diego trailed early as Jaguars kicker Josh Scobee managed to get a 48-yard field goal, along with RB Maurice Jones-Drew getting a 1-yard TD run.
In the fourth quarter, the Chargers tried to make a comeback as QB Philip Rivers completed a 24-yard TD pass to TE Antonio Gates which would be the last scoring play as Jacksonville's defense held on to win.
Coming off their home win over the Ravens, the Chargers flew to Arrowhead Stadium for a Week 13 AFC West rematch with the Kansas City Chiefs.
In the second quarter, Kansas City regained the lead as QB Damon Huard completed a 2-yard TD pass to DE Jared Allen.
Coming off their divisional road win over the Chiefs, the Chargers flew to LP Field for a Week 14 intraconference duel with the Tennessee Titans.
In the third quarter, the Chargers got on the board as kicker Nate Kaeding nailed a 20-yard field goal, yet Tennessee responded with RB Chris Brown getting a 7-yard TD run.
In the second quarter, San Diego continued its domination with Kaeding getting a 22-yard field goal and LB Shaun Phillips returning an interception 18 yards for a touchdown.
Coming off their Christmas Eve victory of the Broncos, the Chargers ended the regular season at McAfee Coliseum for a Week 17 AFC West rematch with the Oakland Raiders.
In the third quarter, the Chargers increased their lead with kicker Nate Kaeding getting a 36-yard field goal, along with rookie LB Jyles Tucker recovering a Raider fumble in the endzone for a touchdown.
3 seed, the Chargers began their playoff run at home against the sixth-seeded Tennessee Titans, in a rematch of Week 14, which saw San Diego trail early, then rally to tie the game in the fourth quarter and win in overtime.
In the third quarter, the Chargers rallied to take the lead with kicker Nate Kaeding nailing a 20-yard field goal, along with QB Philip Rivers completing a 25-yard TD pass to WR Vincent Jackson.
Coming off their wild card home win over the Titans, the Chargers flew to the RCA Dome for their AFC Divisional duel with the second-seeded/defending Super Bowl champion Indianapolis Colts, in a rematch of Week 10.
After squeaking out their victory over Indianapolis, San Diego then traveled to Foxborough, Massachusetts to take on the New England Patriots in the AFC Championship Game in a rematch of Week 2.
Despite the Patriots being heavily favored to win by a large margin and advance to Super Bowl XLII, the game remained tight throughout, as the Chargers kept the score at 14–12 through the third quarter.