Later, kicker Jeff Reed made a 26-yard field goal, while Roethlisberger completed a 40-yard TD pass to WR Santonio Holmes.

San Francisco recovered the fumble at the Pittsburgh 22 and drove to the 4, but was held to another Nedney field goal, this one from 22 yards out, to cut the Steelers' lead to 1.

The teams exchanged punts until late in the second quarter, when Pittsburgh drove 80 yards on 12 plays which culminated in a Roethlisberger touchdown pass to Jerame Tuman to give the Steelers a 14–6 lead into the half.

Referee Gerry Austin ruled instead that the ball had hit the ground, and that the pass was therefore incomplete (the Niners still won the challenge, as the original call of an interception was overturned).

Smith forced a throw into coverage, and it was intercepted by Steeler cornerback Bryant McFadden and returned for a touchdown to give Pittsburgh a commanding 30–9 lead.

Near the end of the first quarter, Pittsburgh delivered the first punch as QB Ben Roethlisberger completed a 43-yard TD pass to WR Santonio Holmes for the only score of the period.

However, after a scoreless second quarter, the Cardinals responded with back-up QB Kurt Warner completing a 6-yard TD pass to WR Jerheme Urban for the only score of the period.

In the fourth quarter, things went wrong for the Steelers as Arizona took the lead with WR Steve Breaston returning a punt 73 yards for a touchdown, while RB Edgerrin James got a 2-yard TD run.

at Heinz Field, Pittsburgh, Pennsylvania Trying to rebound from their road loss to the Cardinals, the Steelers went home for a Week 5 interconference duel with the Seattle Seahawks, in the rematch of Super Bowl XL.

After a scoreless first quarter, the Steelers drew first blood with QB Ben Roethlisberger completing a 13-yard TD pass to TE Heath Miller to lead 7–0 at halftime.

They were able to give their injured players an extra week to heal as Hines Ward, Santonio Holmes, Troy Polamalu, and Casey Hampton were all sidelined due to injuries.

In the second quarter, the Steelers struggled as Cutler completed a 1-yard TD pass to FB Cecil Sapp, along with DE Tim Crowder returning a fumble 50 yards for a touchdown.

With 2:16 left in the second quarter on 4th-and-1 at the Steelers 2, Cincinnati chose to kick a 20-yard field goal and received loud boos from the hometown crowd upon successfully doing so.

In the third quarter, Pittsburgh increased its lead with kicker Jeff Reed nailing a 22-yard field goal, while the defense continued to shut down Baltimore's offense.

Members included Joe Greene, Terry Bradshaw, Franco Harris, Jerome Bettis, Rod Woodson, John Stallworth, Lynn Swann, and Mel Blount.

at Heinz Field, Pittsburgh, Pennsylvania Coming off their dominating Monday Night performance against the Ravens, the Steelers stayed at home for Round 2 of the 2007 Rust Belt series against the Cleveland Browns.

In the second quarter, Cleveland increased its lead with Anderson completing a 2-yard TD pass to FB Lawrence Vickers, while Pittsburgh only managed to have Reed kick a 35-yard field goal.

In the third quarter, Pittsburgh began to come back as QB Ben Roethlisberger completed a 12-yard TD pass to WR Hines Ward for the only score of the period.

at Giants Stadium, East Rutherford, New Jersey Coming off their season-sweep over the Browns, the Steelers flew to The Meadowlands for a Week 11 intraconference duel with the New York Jets.

In the first quarter, Pittsburgh surprisingly fell behind early as Jets QB Kellen Clemens completed a 1-yard TD pass to TE Chris Baker, along with kicker Mike Nugent getting a 25-yard field goal.

Even worse, the Steelers highly ranked rushing defense allowed its first 100-yard rusher since 2005 (Edgerrin James of the Colts) as RB Thomas Jones got 30 carries for 117 yards.

Coming off their disappointing loss to the Jets, the Steelers went home for a Week 12 Monday Night intraconference duel with the winless Miami Dolphins.

In the end, Pittsburgh came through with kicker Jeff Reed nailing the game-winning 24-yard field goal with 17 seconds left for the game's lone points.

Afterwards, the Steelers responded with QB Ben Roethlisberger completing a 32-yard TD pass to RB Najeh Davenport, along with Reed kicking a 44-yard field goal.

at Heinz Field, Pittsburgh, Pennsylvania Hoping to rebound from their road loss to the Patriots, the Steelers went home for a Week 15 duel with the Jacksonville Jaguars.

In the fourth quarter, Pittsburgh ended the game with Reed nailing a 29-yard field goal and CB Ike Taylor returning an interception 51 yards for a touchdown.

In the first quarter, the Steelers trailed early as Ravens RB Musa Smith got a 2-yard TD run, along with kicker Matt Stover managed to get a 28-yard field goal.

In the third quarter, Baltimore increased its lead with QB Troy Smith completing a 15-TD pass to WR Devard Darling for the only score of the period.

4 seed, the Steelers began their playoff run at home in the AFC Wildcard Round against the fifth-seeded Jacksonville Jaguars in a rematch of Week 15 where Pittsburgh nearly came back to win.

In the second quarter, Pittsburgh trailed as CB Rashean Mathis returned an interception 63 yards for a touchdown and QB David Garrard completed a 43-yard TD pass to Jones-Drew.