The Colts remained under the supervision of head coach Tony Dungy and played all of their home games in the RCA Dome in Indianapolis, Indiana.

In the first quarter, Indianapolis began their year with Super Bowl MVP QB Peyton Manning completing a 27-yard TD pass to WR Marvin Harrison for the only score of the period.

In the second quarter, the Saints would get their only touchdown of the game with former Colts DB Jason David returning a fumble 55 yards, while kicker Olindo Mare would get a 34-yard field goal.

During the third quarter, RB Joseph Addai got a 2-yard TD run, while Manning hooked up with WR Reggie Wayne on a 28-yard touchdown pass.

In the fourth quarter, Indianapolis sealed the victory with Vinatieri getting a 33-yard field goal, Manning & Wayne hooking up with each other again on a 45-yard TD pass, and DB Matt Giordano returning an interception 83 yards for a touchdown.

In the second quarter, the Colts increased their lead with QB Peyton Manning completing a 22-yard TD pass to TE Dallas Clark.

Scoring Summary at Reliant Stadium, Houston, Texas Game Summary Following their fierce divisional road win over the Titans, the Colts flew to Reliant Stadium for an AFC South duel with the Houston Texans (who were the last team Indianapolis lost to en route to their Super Bowl championship).

In the fourth quarter, Houston tried to catch up with RB Samkon Gado getting a 1-yard TD run, while Indianapolis got its final score of the game with a Vinatieri kicking a 35-yard field goal.

In the first quarter, Indianapolis trailed early with Broncos kicker Jason Elam getting a 35-yard field goal, while QB Jay Cutler 7-yard TD pass to WR Brandon Marshall.

In the fourth quarter, Indianapolis managed to put the game away with Manning's 5-yard TD pass to WR Reggie Wayne, along with kicker Adam Vinatieri nailing a 22-yard field goal.

In the first quarter, the Colts got the first strike with QB Peyton Manning completing a 10-yard TD pass to TE Dallas Clark for the only score of the period.

In the second quarter, Indianapolis increased its lead with rookie RB Kenton Keith getting a 1-yard TD run (with a blocked PAT).

In the second quarter, the Colts increased its lead with QB Peyton Manning getting a 1-yard TD run, along with kicker Adam Vinatieri getting a 36-yard field goal.

In the fourth quarter, the Colts wrapped up another win with Vinatieri nailing a 20-yard field goal and Manning completing a 35-yard TD pass to TE Dallas Clark.

In the first quarter, Indianapolis trailed early as the Panthers capped off an 11-minute and 1 second opening drive with RB DeShaun Foster getting a 3-yard TD run.

The Patriots then stopped a drive by the Colts when Peyton Manning was hit by Jarvis Green and fumbled the ball into the hands of Rosevelt Colvin with just under three minutes to go.

Peyton Manning would lead the Colts down the field and capped the drive with an 8-yard TD pass to receiver Reggie Wayne.

Receivers Marvin Harrison and Anthony Gonzalez, left tackle Tony Ugoh, and tight end Dallas Clark missed the game.

In the second half the Colts would cruise to victory by adding a Joseph Addai rushing touchdown and Adam Vinatieri field goal to make the final score 31–13.

In the third quarter, Jacksonville tried to come back as QB David Garrard completed a 2-yard TD pass to TE Marcedes Lewis for the only score of the period.

Afterwards, Manning and Addai hooked up with each other on a 19-yard TD pass, while rookie CB Michael Coe blocked a punt, causing it go through the back of Baltimore's end zone for a safety.

In the first quarter, Indianapolis jumped out to an early 10–0 lead with kicker Adam Vinatieri managing to get a 22-yard field goal, while CB T.J. Rushing returned a punt 90 yards for a touchdown.

In the second quarter, the Raiders got on the board with QB Josh McCown completing a 3-yard TD pass to WR Ronald Curry for the only score of the period.

Afterwards, Indianapolis sealed the win as QB Peyton Manning completed a 20-yard TD pass to rookie WR Anthony Gonzalez.

With 9:09 left in the third quarter backup quarterback Jim Sorgi throw a 3-yard touchdown pass to Craphonso Thorpe to give the Colts a 10–7 lead.

Scoring Summary at RCA Dome, Indianapolis, Indiana Game Summary Despite the loss of starting quarterback Philip Rivers and running back LaDainian Tomlinson (the NFL's leading rusher during the season), San Diego still managed to defeat the defending Super Bowl champion Colts, forcing them to turn the ball over on downs twice in San Diego territory in the final minutes of the game.

The Colts started out the game strong, driving 76 yards and scoring with Peyton Manning's 25-yard touchdown pass to tight end Dallas Clark.

Manning responded by completing 3 passes for 42 yards on a 44-yard drive that ended with an Adam Vinatieri field goal to give the Colts a 10–7 lead.

On the Chargers ensuing drive, Rivers threw a 22-yard completion to Chambers and followed it up with a 56-yard pass to running back Darren Sproles, a special teams returner who was brought in on offense as an extra receiver.

Indianapolis' defense managed to force a punt, but the Colts turned the ball over on downs again with 53 seconds left and San Diego ran out the rest of the clock.