The 2010 African Handball Champions League was the 32nd edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from October 21–30, 2010 at the Complexe Sportif Mohammed V in Casablanca, Morocco, contested by 17 teams and won by Étoile Sportive du Sahel of Tunisia.

[1] Blessing GS Pétroliers Novotel Primeiro de Agosto Al-Nasr Benghazi Inter Club JSE Skikda Kabuscorp Minuh Yaoundé Rabita de Casablanca

US Gorée Zamalek AS Sonaby Étoile du Sahel FAP Yaoundé Stade Mandji [2] * Note:   Advance to quarter-finals   Relegated to 9-12th classification   Relegated to 13-16th classification * Note:   Advance to quarter-finals   Relegated to 9-12th classification   Relegated to 13-16th classification * Note:   Advance to quarter-finals   Relegated to 9-12th classification   Relegated to 13-16th classification * Note:   Advance to quarter-finals   Relegated to 9-12th classification   Relegated to 13-16th classification [3] * Penalty for failing to pay participation fees [4]