The 2010 African Handball Cup Winners' Cup was the 26th edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from April 7–17, 2010 at the Palais des Sports de Ouagadougou in Ouagadougou, Burkina Faso, contested by 16 teams and won by Zamalek Sporting Club of Egypt.

Curiaces Munisport Zamalek Al Ahly Amin Elam Blessing Minuh Yaoundé AS Sonabel Interclube Red Star US Gorée Al-Nasr JSE Skikda RC Flowers

[1] * Note:   Advance to quarter-finals   Relegated to 9-16th classification * Note:   Advance to quarter-finals   Relegated to 9-16th classification * Note:   Advance to quarter-finals   Relegated to 9-16th classification * Note:   Advance to quarter-finals   Relegated to 9-16th classification

* Note:   Advance to semi-finals   Relegated to 5-8th classification * Note:   Advance to semi-finals   Relegated to 5-8th classification