The 2010 Heineken Open was a tennis tournament played on outdoor hard courts.

It was the 35th edition of the Heineken Open, and was part of the ATP World Tour 250 series of the 2010 ATP World Tour.

Unseeded John Isner won the singles title.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw through qualifying: The following player received the lucky loser spot: John Isner defeated Arnaud Clément, 6–3, 5–7, 7–6(7–2).

Marcus Daniell / Horia Tecău defeated Marcelo Melo / Bruno Soares, 7–5, 6–4.