The 2010 MLS Cup Playoffs was the postseason tournament subsequent to Major League Soccer's 2010 season.

The playoffs began on October 30, with the Los Angeles Galaxy defeating the Seattle Sounders FC in the quarterfinal-round.

Three weeks later, the Colorado Rapids defeated FC Dallas 2-1 in the Cup final at BMO Field in Toronto, Ontario.

Of the eight MLS clubs to earn qualification into the tournament, only four of them qualified the season before; Columbus Crew, Los Angeles Galaxy, Seattle Sounders FC, and the defending-champions, Real Salt Lake.

In all rounds, the tie-breaking method would be two 15-minute periods of extra time, followed by penalty kicks if necessary.