Rafael Nadal defeated Novak Djokovic in the final, 6–4, 5–7, 6–4, 6–2 to win the men's singles tennis title at the 2010 US Open.

It was his first US Open title and ninth major title overall, completing the career Golden Slam and becoming the first man to win the Surface Slam (majors on clay, grass, and hard courts in the same calendar year).

Juan Martín del Potro was the reigning champion, but did not participate this year after undergoing a wrist operation in May and only starting to practice again in August.

[1][2] For the first time in tournament history, no American man was seeded in the top eight.

Click on the seed number of a player to go to their draw section.