The 2012 African Handball Cup Winners' Cup was the 28th edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from April 19–30, 2012 at the Salle El-Menzah in Tunis, Tunisia, contested by 13 teams and won by Étoile Sportive du Sahel of Tunisia.

[1] Al-Jazeera ES Sahel FAP Yaoundé JS Kinshasa Club Africain Red Star Union Sportive Wydad Smara Al-Hilal Kano Pyramid RS Berkane Saint-Michel Zamalek * Note:   Advance to quarter-finals   Relegated to 9-12th classification * Note:   Advance to quarter-finals   Relegated to 9-12th classification** Penalty for failing to pay participation fees * Note:   Advance to quarter-finals   Relegated to 9-12th classification