The 2016 African Women's Handball Cup Winners' Cup was the 32nd edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from May 5–20, 2016 in one venue: the Salle Al Jadida, in Laayoune, Western Sahara, contested by 8 teams and won by Clube Desportivo Primeiro de Agosto of Angola thus successfully defending its tile.

[1][2]

FAP Yaoundé Primeiro de Agosto Africa Sports Mikishi Progresso

[3] * Note:   Advance to quarter-finals * Note:   Advance to quarter-finals 2016 African Women's Handball Champions League