The 2018 African Handball Cup Winners' Cup was the 24th edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from April 13–22, 2018 and took place in Cairo, Egypt, contested by 14 teams and won by Al Ahly SC of Egypt.

[1] JS Kinshasa Kembata Durame Phoenix Gabon Widad Smara FAP Yaoundé Inter Club Sporting Heliopolis JS Lubumbashi Kirkos Red Star Al Ahly SC Al-Ittihad AS Minuh [2] * Note:   Advance to quarter-finals   Relegated to 9th classification * Note:   Advance to quarter-finals   Relegated to 9th classification * Note:   Advance to quarter-finals   Relegated to 9th classification * Note:   Advance to quarter-finals   Relegated to 9th classification [3] 2018 African Handball Champions League