The 2019 season was the Carolina Panthers' 25th in the National Football League (NFL), and their ninth and last under head coach Ron Rivera.

The Panthers played in London as part of the NFL International Series for the first time in franchise history.

They suffered an eight-game losing streak (their worst since 2001, where they finished 1–15) to end the season badly with a 5–11 record.

However on December 3, two days after a loss to the Washington Redskins, Rivera was fired after nearly nine seasons as head coach and due to new ownership wanting a change within the organization.

[2][3] Cam Newton suffered a season-ending foot injury after playing in the first 2 weeks of the season, and was replaced by rookie quarterbacks Will Grier and Kyle Allen.

On October 7, Kyle Allen became the first undrafted quarterback to win their first 4 starts since Kurt Warner did so during the St. Louis Rams' 1999 Super Bowl-winning season.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

The Panthers answered back with a Christian McCaffrey touchdown plus a Slye field goal, making it 16–10.

Arizona started off with the ball in the second half, and capping a 75-yard drive, Kyler Murray completed a 3-yard pass to David Johnson for a touchdown.

The Cardinals reduced their deficit to a single point on their next series, as Zane Gonzalez made a 47-yard field goal.

In the fourth quarter, Greg Olsen picked up another 3-yard touchdown catch and Joey Slye added a 36-yard field goal to give the Panthers a 38–20 win, improving them to 1–2.

This game would give the Panthers franchise all-time win number 200, with both regular season and playoff record at 200-203-1 at that point.