On December 2, Brittany Bowlen, 29, made her return to the Broncos' organization with a senior management position of vice president of strategic initiatives, following the end of her employment with McKinsey & Company.

After burning all of their timeouts, the Broncos finally reached the end zone with 37 seconds remaining, with Flacco connecting with wide receiver Emmanuel Sanders on a 7-yard touchdown pass.

The Broncos then attempted the game-tying extra point, which McManus missed wide right; however, Bears' cornerback Buster Skrine was whistled for an offsides penalty.

On the first play, Broncos' linebacker Bradley Chubb was whistled for a questionable roughing the passer penalty on Bears' quarter Mitchell Trubisky, which added 15 yards to a 5-yard completion to tight end Trey Burton.

Trubisky completed a 25-yard pass to wide receiver Allen Robinson in the middle of the field to the Broncos' 35-yard line, and the Bears' final timeout was called with one second remaining.

Then early in the third quarter, linebacker Jaire Alexander forced a fumble off Broncos tight end Noah Fant at the Denver 37-yard line, and Jones' second rushing touchdown—from 1 yard out—increased the Packers' lead to 24–10.

After forcing the Packers to punt, the Broncos advanced to the Green Bay 38-yard line late in the third quarter; however, Flacco was intercepted by safety Darnell Savage Jr.

On the opening possession of the second half, the Jaguars pulled to within a 17–13 deficit, with a 16-play, 75-yard drive, culminating in a 7-yard touchdown pass from quarterback Gardner Minshew to running back Ryquell Armstead.

After the Broncos went three-and-out on their first possession of the second half, the Jaguars took a 20–17 lead, with Minshew, starting in place of the injured Nick Foles, connecting on an 18-yard touchdown pass to tight end James O'Shaughnessy.

On the second play of the Jaguars' game-winning drive, linebacker Von Miller was whistled for a roughing the passer penalty after the Broncos forced their first fumble of the season.

The Chargers reached the Broncos' 1-yard line with seven seconds remaining before halftime, with Rivers completing a short pass to running back Austin Ekeler near the left sideline.

However, Broncos' safety Kareem Jackson forced a fumble before Ekeler could break the plane of the goal line near the pylon, and the football went out of the corner of the end zone for a touchback, keeping the Chargers scoreless.

The Titans' offense did not advance past midfield until the fourth quarter, and reached the Broncos' 13-yard line with 9:22 remaining; however, Tannehill was sacked by defensive end DeMarcus Walker on a 4th-and-4.

First, quarterback Patrick Mahomes connected on a 21-yard touchdown pass to wide receiver Mecole Hardman, which was followed by a pair of field goals by placekicker Harrison Butker—a 33-yarder near the end of the first quarter and a 20-yarder midway through the second.

Mahomes was replaced by backup quarterback Matt Moore, who launched a 57-yard touchdown pass to wide receiver Tyreek Hill in the third quarter, and Butker later added a 39-yard field goal in the fourth.

After a scoreless first quarter, the Broncos failed to capitalize on two red zone opportunities, settling for a pair of short field goals by placekicker Brandon McManus in the second quarter—from 21 and 29 yards out.

On the first play, Brissett evaded a sack by linebacker Von Miller, and completed a 35-yard pass to wide receiver T. Y. Hilton on the right sideline that was reviewed, but upheld by instant replay.

The Browns responded on their next drive, and with 10:53 remaining in the fourth quarter, Mayfield connected with wide receiver Jarvis Landry on a 9-yard touchdown to narrow the Broncos' lead to 24–19.

The Broncos recovered a fumble off return specialist Ameer Abdullah on the ensuing kickoff, and were hoping to increase their lead prior to halftime; however, on the next play, Allen was intercepted by safety Andrew Sendejo near the goal line.

On the opening possession, Cousins connected on a 10-yard touchdown pass to tight end Irv Smith Jr. After a 41-yard field goal by McManus increased the Broncos lead to 23–7, the Vikings pulled to within a 23–20 deficit within the first five minutes of the fourth quarter.

After an 18-yard touchdown pass from Josh Allen to wide receiver Cole Beasley gave the Bills a 13–0 lead on the first possession of the second half, the Broncos' only scoring play was a 45-yard field goal by placekicker Brandon McManus midway through the third quarter.

Quarterback Drew Lock, the Broncos' second-round draft selection, made his NFL debut, after missing the first eleven games due to a sprained thumb sustained during the preseason.

The Broncos had one final possession, and instead of kneeling down for an overtime period, Lock attempted a deep pass to Sutton that was incomplete at the Chargers' 35-yard line with only three seconds remaining.

Chiefs' quarterback Patrick Mahomes connected on a pair of touchdown passes to wide receiver Tyreek Hill—a 41-yarder on their opening possession and a 5-yarder in the third quarter that put the game out of reach.

However, the Broncos took the lead for good early in the fourth quarter, with quarterback Drew Lock completing a shovel pass to wide receiver DaeSean Hamilton for a 3-yard touchdown.

The Raiders faced a 3rd-and-goal at the Broncos' 5-yard line on their next possession, and a 5-yard pass from quarterback Derek Carr to wide receiver Hunter Renfrow was initially ruled a touchdown.

However, after a false start and an unnecessary roughness penalty on offensive tackle Garett Bolles pushes the Broncos back 15 yards, McManus missed wide-right on a 57-yard field goal attempt, giving the Raiders one last possession at their own 47-yard line.

On the eighth play of the drive, the Raiders finally reached the end zone, with a 3-yard pass from Carr to Renfrow to pull to within a 16–15 deficit with 11 seconds remaining in the game.

[56] However, he threw for 1,822 yards and only six touchdown passes, prior to discovery of a herniated disc in his neck that ended his season following the team's Week 8 loss to the Indianapolis Colts.

[130] Linebacker Von Miller was selected to the 2020 Pro Bowl, while wide receiver Courtland Sutton, safety Kareem Jackson and return specialist Diontae Spencer were named alternates.