The 2019 season was the New Orleans Saints' 53rd in the National Football League (NFL), their 44th playing home games at the Mercedes-Benz Superdome and their 13th under head coach Sean Payton.

Despite losing Drew Brees to a thumb injury during a week 2 rematch against the Rams, the Saints went 5–0 in the games following his absence under backup Teddy Bridgewater, and won the NFC South for the third consecutive season after beating their division rival Atlanta Falcons on Thanksgiving night.

The Saints matched their record from the previous year after defeating their divisional rivals Carolina Panthers in week 17, sweeping them for the second time in three seasons, but were not able to secure a first round bye due to a three way tiebreaker with the San Francisco 49ers and Green Bay Packers.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.

With less than one minute to play, Texans quarterback Deshaun Watson threw a go-ahead touchdown to wide receiver Kenny Stills; however, the Saints and Brees were able to move the ball down the field and kicker Wil Lutz kicked a 58–yard field goal to lead the team to victory.

On defense, Cam Jordan strip sacked Jared Goff and returned a fumble 87 yards for a touchdown, which was controversially overturned.

The Seahawks scored 20 points in the final period, but a short touchdown run from Alvin Kamara proved the difference between the two teams, to move the Saints to 2–1 on the season.

The Saints found yet another way to win a game without star quarterback Drew Brees and with Teddy Bridgewater at the helm, as Wil Lutz kicked four field goals.

Running back Latavius Murray, filling in for an injured Alvin Kamara, rushed for over 100 yards on the ground.

The Saints stifled the Bears offense for the majority of the game before giving up two touchdowns in garbage time.

With Alvin Kamara still sidelined, Drew Brees returned after missing five weeks following thumb surgery.

The Saints defense intercepted Buccaneers QB Jameis Winston four times, including a pick-six by safety Marcus Williams to ice the game in the fourth quarter.

The Saints defense played one of its best games of the season with 9 sacks of Matt Ryan and forced 3 takeaways.

Taysom Hill blocked a punt early, caught a touchdown pass and ran one in from 30 yards out.

Although Brees found Tre'Quan Smith late in the game to take a 46–45 lead, Garoppolo connected with tight end George Kittle who ran past several Saints defenders on one of the iconic plays of the season.

With the Titans driving and only down 3, Kalif Raymond was tackled by C. J. Gardner-Johnson and lost a fumble; the hit was controversially not flagged.

Linebacker A. J. Klein intercepted an errant pass by Panthers quarterback Will Grier and returned it for a 14-yard pick-six.

However, they were unable to clinch a first-round bye as the Green Bay Packers and San Francisco 49ers also won.