The 2020–21 CAF Champions League qualifying rounds were played from 28 November 2020 to 6 January 2021.
[1][2] A total of 54 teams competed in the qualifying rounds to decide the 16 places in the group stage of the 2020–21 CAF Champions League.
[3] The draw for the qualifying rounds was held on 9 November 2020 at the CAF headquarters in Cairo, Egypt.
[4][5] The entry round of the 54 teams entered into the draw was determined by their performances in the CAF competitions for the previous five seasons (CAF 5-year ranking points shown in parentheses).
In the qualifying rounds, each tie was played on a home-and-away two-legged basis.
If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations III.
[2] The bracket of the draw was announced by the CAF on 9 November 2020.
Al Ahly Benghazi won on walkover after Mekelle 70 Enderta were not able to present themselves with 15 players (including 1 goalkeeper) for the first leg in Cairo citing the Tigray conflict.
[8][9] Gazelle won on walkover after GR/SIAF failed to appear for the first leg in N'Djamena.
Zamalek won on walkover after Gazelle were disqualified by CAF for failing to appear for the first leg in Cairo.