The Broncos failed to improve on their 7–9 record from 2019, while decimated by numerous injuries and struggling with poor offensive performances, ranking in the bottom quarter in several statistical categories.

However, on the Broncos' next possession, running back Melvin Gordon lost a fumble at the 25-yard line, and with a short field, the Titans capitalized five plays later, with quarterback Ryan Tannehill connecting with tight end MyCole Pruitt on a 1-yard touchdown pass.

Each team exchanged punts on their next two possessions, and the Broncos failed to convert a critical third down play, in which Lock overthrew wide receiver DaeSean Hamilton in the end zone.

The only scoring play by the Broncos in the first half came courtesy of a 49-yard field goal by placekicker Brandon McManus, who missed wide right on a 58-yard attempt later in the second quarter.

Broncos' punter Sam Martin fumbled a punt snap early in the fourth quarter and was tackled in the end zone for a safety, increasing the Steelers' lead to 26–14.

However, the Broncos' defense forced a fumble near midfield on the Steelers' next possession, and six plays later, Driskel connected with running back Melvin Gordon on a 16-yard touchdown pass midway through the fourth quarter.

Punter Sam Martin had a punt blocked in the first quarter, and the Broncos' defense surrendered three touchdown passes to Buccaneers' quarterback Tom Brady—two of which went to wide receiver Mike Evans.

Driskel was later benched in the fourth quarter in favor of backup quarterback Brett Rypien, who drove the Broncos' offense deep into Buccaneers' territory with four minutes remaining in the game, but threw a game-sealing interception near the goal line.

On the Broncos' next possession, Rypien was intercepted by Desir, and Jets' placekicker Sam Ficken missed wide-left on a 46-yard field goal attempt.

Rypien then threw two interceptions, the first of which was returned by Desir for a 35-yard touchdown (with an unsuccessful two-point conversion attempt), the second of which set up a 36-yard field goal by Ficken that temporarily gave the Jets a 28–27 lead with 6:33 remaining in the game.

Two field goals came courtesy of two turnovers off the Patriots—an interception of quarterback Cam Newton on the Patriots' first possession and a forced fumble off tight end Ryan Izzo by Broncos' cornerback Michael Ojemudia in the third quarter.

Quarterback Drew Lock misfired on two potential touchdown passes to rookie tight end Albert Okwuegbunam and came up just short of the goal line on a sideline scramble.

Multiple mistakes doomed the Broncos in snowy and foggy conditions, in a 43–16 loss to their AFC West rivals, the Kansas City Chiefs.

Broncos' running back Phillip Lindsay rushed for 79 yards, before suffering a concussion after a helmet-to-helmet hit from Sorensen late in the first half.

Throughout their next six possessions, the Broncos' offense was stymied by the Chargers' defense, failing to advance past their own 44-yard line (including a kneel down by quarterback Drew Lock on the last play of the first half).

The Broncos narrowed the deficit to 24–17 early in the fourth quarter, with Lock connecting on a 9-yard touchdown pass to tight end Albert Okwuegbunam.

Following a 20-yard run by Lindsay, coupled with a 15-yard personal foul penalty on Chargers' safety Nasir Adderley, Lock threw a 40-yard touchdown pass to wide receiver DaeSean Hamilton.

Then Okwuegbunam drew two defensive pass interference penalties on the Chargers—the first on a 3rd-and-8 at the 1:30 mark, and the other in the end zone on a 4th-and-4 that gave the Broncos the football at the 1-yard line with one second remaining in the game.

The Broncos finally reached the end zone early in the fourth quarter, with quarterback Drew Lock throwing a 20-yard touchdown pass to wide receiver Jerry Jeudy.

The Broncos' only scoring play was a 58-yard field goal by placekicker Brandon McManus, which came after gaining only one yard following an interception of Saints' quarterback Taysom Hill midway through the third quarter.

After being outscored by the Chiefs by a combined score of 96–25 in their previous three meetings, the Broncos hung tough with the defending Super Bowl champions on Sunday Night Football.

[134] After a three-and-out to the start the fourth quarter, the Broncos' defense forced a punt after a 48-yard touchdown pass from Mahomes to wide receiver Tyreek Hill was negated by an offensive holding penalty.

On the Broncos' next possession, Lock was unable to connect on two critical pass attempts to wide receivers Jerry Jeudy and K. J. Hamler, only making it to midfield and were forced to punt.

Broncos' quarterback Drew Lock was strip-sacked on the first possession of the second half, which resulted in a 21-yard fumble return by defensive end Jerry Hughes.

The Broncos' offense reached the red zone on their initial possession of the game, but quarterback Drew Lock was intercepted by Chargers' cornerback Casey Hayward and placekicker Brandon McManus hit the left upright on a 37-yard field goal attempt early in the second quarter.

Broncos' cornerback Michael Ojemudia forced a fumble off Raiders' tight end Darren Waller on the first play of the second quarter; however, McManus missed wide left on a 56-yard field goal attempt.

On the next play, Gordon gained 19 yards for what would have been a game-clinching first down; however, it was nullified by an offensive holding penalty on tight end Noah Fant.

Following an incomplete pass from Lock to wide receiver Diontae Spencer, McManus attempted a 63-yard field goal, however, it was blocked, giving the Raiders the win and their first season sweep of the Broncos since 2010.

Undrafted wide receiver Kendall Hinton, who played quarterback at Wake Forest and was promoted from the practice squad, served as the emergency starter, with running back Royce Freeman as the backup.

[161] On October 5, the Broncos were approved to continue admitting 5,700 fans for each remaining home game, and had hopes of increasing spectator capacity later in the season.