The Preseason Media Poll and Preseason All-ACC teams were voted on after a tipoff event held at the Charlotte Marriott City Center in Charlotte, North Carolina on October 13, 2021.

[13] At the media day, both the head coaches and the Blue Ribbon Panel predicted that NC State would be league champion.

The conference returned to an 18-game schedule after playing 20 games last season due to the COVID-19 pandemic.

[32] Cameron Swartz – Boston College Delicia Washington – Clemson Lorela Cubaj – Georgia Tech Emily Engstler – Louisville Hailey Van Lith – Louisville Deja Kelly – North Carolina Elissa Cunane – NC State Olivia Miles – Notre Dame Elizabeth Kitley – Virginia Tech Jewel Spear – Wake Forest Taylor Soule – Boston College Morgan Jones – Florida State Alyssa Ustby – North Carolina Maya Dodson – Notre Dame Aisha Sheppard – Virginia Tech Lotta-Maj Lahtinen – Georgia Tech Kelsey Marshall – Miami Diamond Johnson – NC State Kayla Jones – NC State Teisha Hyman – Syracuse Georgia Amoore – Virginia Tech Maria Gakdeng – Boston College Shayeann Day-Wilson – Duke O’Mariah Gordon – Florida State Makayla Timpson – Florida State Payton Verhulst – Louisville Ja’Leah Williams – Miami Aziaha James – NC State Sonia Citron – Notre Dame Cameron Swartz – Boston College Morgan Jones – Florida State Lorela Cubaj – Georgia Tech Emily Engstler – Louisville Hailey Van Lith – Louisville Deja Kelly – North Carolina Elissa Cunane – NC State Maya Dodson – Notre Dame Olivia Miles – Notre Dame Elizabeth Kitley – Virginia Tech Taylor Soule – Boston College Delicia Washington – Clemson Kayla Jones – NC State Aisha Sheppard – Virginia Tech Jewel Spear – Wake Forest Kelsey Marshall – Miami Georgia Amoore – Virginia Tech Maria Gakdeng – Boston College Shayeann Day-Wilson – Duke O’Mariah Gordon – Florida State Makayla Timpson – Florida State Payton Verhulst – Louisville Ja’Leah Williams – Miami Aziaha James – NC State Sonia Citron – Notre Dame The ACC had seven players selected in the WNBA Draft.

This was the seventeenth consecutive year the league had a player selected, which is the longest of any conference.