[2] Governed by the Danish FA, the season was launched on 7 August 2021 with two fixtures in the preliminary round (Dalum/Næsby vs B.93 and Odense Q vs Næstved HG) and concluded with the last four matches on 20 November 2021.
The fixtures for the 2021–22 season were announced by the Danish FA's tournament committee and featured a twenty weeks long winter break.
Due to economic difficulties and the lack of an elite organization, the women's football department of Herlufsholm GF approached Næstved IF Fodbold with the intention of creating a women's superstructure between the two clubs, which resulted in Næstved HG Kvindeelite being formed on 1 July 2021, playing based on the league license of Herlufsholm GF.
[17] In December 2021, Sundby BK announced that five investors would contribute to the professional and commercial department involving the first men's and women's teams.
[18] While the 2020–21 division final was won by Herlufsholm GF with 6–1, in the present season's first encounter between the two teams Vildbjerg SF secured a 3–2 away win against NIF HG seven minutes before full time.
[19][18] Næstved HG's losing streak was extended to six games in a row, producing a bottom place in the table, and resulting in the management's sacking of head coach Jeppe Tengbjerg during the women's international match window.
[20][21] The first win of the season for Næstved HG was achieved in the seventh round, in the first match under the new head coach, and former sports director, Steen "Olsen" Hansen, by defeating Dalum/Næstby at their own home ground.
[25][21] Odense Q gained an early lead in the league standings by procuring five victories and five clean sheets in the first five games, with Swedish goalkeeper Isabelle Granlund recording eight clean sheets by the end of the fall season and captain Kamilla Ørskov Jensen shared top scorer title in the preliminary round together with Sissel Bøje of Sundby BK, both scoring nine goals.
During the summer break, two new superstructures were formed, with Næstved HG assuming the league license of Herlufsholm GF, while Dalum/Næsby took Næsby BK's place in the second division.