They played their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference.

[1] In Otzelberger's first season as head coach he claimed the best start to an Iowa State coaching career by winning his first 10 games,[2] ultimately winning his first 12 games before losing at home to #1 Baylor to end his unbeaten start at Iowa State.

Following the winless conference season, the school fired head coach Steve Prohm after six years in Ames.

On June 2, the Big 12 announced matchups as part of the Big East-Big 12 Battle, with Iowa State traveling to Omaha, Nebraska to play Creighton and former Iowa State head coach Greg McDermott.

[23] On June 23, it was announced that the Cyclones will face Missouri in the Big 12/SEC Challenge.