The 2021–22 Macedonian Football Cup was the 30th season of North Macedonia's football knockout competition.
Sileks were the defending champions, having won their third title in the previous year.
Matches were played on 15 and 22 September 2021.
The finalists from the previous season (Akademija Pandev and Sileks) received byes.
[1] The draw was held on 2 November 2021.