The winners of the Maltese FA Trophy will earn a place in the first qualifying round of the 2022–23 UEFA Europa Conference League.

[2] Fourteen preliminary round matches played on 7-9 December 2021.

Three matches (Except Gżira United vs Santa Lucia) were Live on TVMNews+ The draw for the Quarter-finals and Semi-finals was held on 5 March 2022.

Valletta reached their twenty-five Maltese FA Trophy finals having won it fourteen times.

Floriana reached their thirty-two finals and had won it twenty times previously.