[2] The number of participating teams was reduced from the 78 of the previous season to 44 clubs.
They were defeated 4–2 by Internazionale in the final after extra time; it was Inter's eighth Coppa Italia title, having won their seventh cup title in 2011.
[4][5] Teams entered the competition at various stages, as follows:[2] The schedule of each round was announced on 12 July 2021.
The quarter-final matches were played between clubs advancing from the round of 16.
Semi-finals (a two-legged round) were played between clubs advancing from the quarter-finals.