2021–22 Eredivisie

Note: Flags indicate national team as has been defined under FIFA eligibility rules.

[1] The winner received a spot in the second qualifying round of the 2022–23 UEFA Europa Conference League.

The seeds were assigned based on the final ranking after the regular season.

The best ranked team got the highest seed (lowest number).

If a match was level at the end of normal playing time, extra time was played (two periods of fifteen minutes each) and followed, if necessary, by a penalty shoot-out to determine the winners.