The first club to be promoted was Ionikos, after beating Ergotelis 2–1 on 19 May 2021.
Ionikos played in the Super League for the first time since the 2006–07 season.
AEL has been relegated to 2021–22 Super League Greece 2, ending their four-year stay in the top flight.
The top six teams from Regular season will meet twice (10 matches per team) for places in 2022–23 UEFA Champions League and 2022–23 UEFA Europa Conference League as well as deciding the league champion.
Annual awards were announced on 12 December 2022[102] *only in pre-HFF championships